Long-Chain Fatty Acid Receptors Mediate Relaxation of the Porcine Lower Esophageal Sphincter
Long-chain fatty acids activate the free fatty acid receptor 1 (FFA1) and FFA4.In the gastrointestinal system, FFA1 and FFA4 have been found in the pancreas and intestine.Fatty food and decreased lower esophageal sphincter (LES) motility are associated with gastroesophageal reflux disease.The effect of long-chain fatty acids on the esophageal motil